interleukin-17F; cytokine ML-1; interleukin-24; IL-24 (IL17F, IL-17F, IL24)

Function

• stimulates the production of other cytokines, including IL-6, IL-8 & GCSF
• regulation of cartilage matrix turnover
• stimulates monocyte & T-cell proliferation
• inhibits angiogenesis.

Structure

homodimer; disulfide-linked

Compartment

secreted

Expression

• expressed in activated, but not resting, CD4+ T-cells & activated monocytes

Pathology

• defects in IL17F are the cause of familial candidiasis type 6

More general terms

• interleukin-17 (IL-17)
• glycoprotein
• oligomerizing protein

Additional terms

• interleukin-24; IL-24; melanoma differentiation-associated gene 7 protein; MDA-7; suppression of tumorigenicity 16 protein (IL24, MDA7, ST16)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=112744
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:112744
• OMIM: https://mirror.omim.org/entry/606496
• OMIM: https://mirror.omim.org/entry/613956
• UniProt: http://www.uniprot.org/uniprot/Q96PD4.html