cyclin-D1-binding protein 1 (Grap2 & cyclin-D-interacting protein, human homolog of maid, CCNDBP1, DIP1, GCIP, HHM)

Function

• may negatively regulate cell cycle progression
• may act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 & blocking E2F-dependent transcription
• interacts with CCND1 & GRAP2
• may also interact with COPS5, RPLP0, SIRT6, SYF2 & TCF3
• phosphorylated

Structure

belongs to the CCNDBP1 family

Compartment

cytoplasm. nucleus

Alternative splicing

named isoforms=4

Expression

• ubiquitously expressed
• expression may increase during differentiation

Pathology

• expression is down-regulated in a variety of tumor types including breast cancer, colon cancer, prostate cancer & rectal cancer
• up-regulated in certain hepatic carcinomas

More general terms

• nuclear protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2358
• OMIM: https://mirror.omim.org/entry/607089
• UniProt: http://www.uniprot.org/uniprot/O95273.html