SH3 domain-containing protein 19 (ADAM binding protein Eve-1, EEN-binding protein, EBP, SH3D19)

Function

• may play a role in regulating A disintegrin & metalloproteases (ADAMs) in signaling of EGFR-ligand shedding
• may be involved in suppression of Ras-induced cellular transformation & Ras-mediated activation of ELK1
• interacts with ADAM12
• isoform 4 & isoform 5 (but not isoform 1 & isoform 2) interact with ADAM9, ADAM10, ADAM15 & ADAM17
• interacts with SH3GL1 SH3 domain
• interacts via SH3 3 & SH3 4 or SH3 4 & SH3 5 domains with SOS2
• probably forms a trimeric complex with SH3GL1 & SOS2
• interacts with SH3YL1

Structure

contains 5 SH3 domains

Compartment

• cytoplasm. nucleus
• recruited to the nucleus by the MLL-EEN fusion protein

Alternative splicing

named isoforms=5

Expression

• widely expressed
• highest levels in heart, skeletal muscle, kidney, liver, placenta, small intestine & lung
• expressed at low levels in colon, thymus, spleen & leukocytes

Notes

uncertain whether Met-1 or Met-4 is the initiator

More general terms

• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1525
• OMIM: https://mirror.omim.org/entry/608674
• UniProt: http://www.uniprot.org/uniprot/Q5HYK7.html