cell division cycle-associated protein 3 (trigger of mitotic entry protein 1, TOME-1, gene-rich cluster protein C8, CDCA3, C8, GRCC8, TOME1)

Function

• F-box-like protein, required for entry into mitosis
• component of SCF complex
• interacts with E3 ligase complexes that mediate ubiquitination & degradation of WEE1 kinase at G2/M phase
• role in ubiquitin conjugation 3rd step
• interacts with SKP1A
• ubiquitinated & degraded by APC/C-Cdh1 complex
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• KEN box is required for the association with APC/C-Cdh1 complex

Compartment

cytoplasm

More general terms

• cell division cycle-associated protein 4 (CDCA)
• phosphoprotein

Component of

• SCF-type E3 ligase complex

Database

• OMIM: https://mirror.omim.org/entry/607749
• UniProt: http://www.uniprot.org/uniprot/Q99618.html