Cyclin-L1 (CCNL1, cyclin L-alpha)
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Function
- transcriptional regulator
- regulation of pre-mRNA splicing process
- regulation of RNA polymerase (putative)
- functions inassociation with cyclin-dependent kinases
- role in 2nd step of splicing
- inhibited by CDK-specific inhibitor p21WAF1
- interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD)
- interacts with CDC2L1 or CDC2L2, SFRS2
Structure
- contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors
- this region probably plays a role in protein-protein interactions
- belongs to the cyclin family, cyclin L subfamily
Compartment
nucleus, nucleoplasm, nuclear speckle
Alternative splicing
- named isoforms=3
- immediate-early gene with independently regulated isoforms; cyclin L alpha, beta, gamma are isoforms
- at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Expression
- ubiquitous expression
- higher expression in thymus
Pathology
- candidate proto-oncogene in head & neck squamous cell carcinomas (HNSCC)
- amplified in several HNSCC
- involved local-regional metastases (putative)