neurogranin (Ng, NRGN, RC3)
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Function
- brain-specific phosphoprotein
- phosphorylated by protein kinase C
- binds calmodulin in the absence of Ca+2
- regulated by RXR
- regulates calmodulin availability in axons & dendritic spines
- plays a role in long-term potentiation & depression
Structure
Expression
- in the cerebral cortex, found in the cell bodies of neurons in layers II-VI, & in apical & basal dendrites of pyramidal neurons
Pathology
- not found in the dendrites in patients with Alzheimer disease
Laboratory
- CSF neurogranin is elevated in patients with Alzheimer disease & to a lesser extent mild cognitive impairment[4]
- plasma exosome neurogranin is diminished in patients with Alzheimer disease & mild cognitive impairment[4]
More general terms
References
- ↑ OMIM https://mirror.omim.org/entry/602350
- ↑ Rampon C, Jiang CH, Dong H, Tang YP, Lockhart DJ, Schultz PG, Tsien JZ, Hu Y. Effects of environmental enrichment on gene expression in the brain. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12880-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11070096
- ↑ UniProt http://www.uniprot.org/uniprot/Q92686.html
- ↑ 4.0 4.1 4.2 Liu W, Lin H, He X et al Neurogranin as a cognitive biomarker in cerebrospinal fluid and blood exosomes for Alzheimer;s disease and mild cognitive impairment. Translational Psychiatry April 29, 2020 PMID: https://www.ncbi.nlm.nih.gov/pubmed/32350238 Free PMC Article https://www.nature.com/articles/s41398-020-0801-2