AMP-activated protein kinase alpha-1 subunit (AMPK alpha-1 chain, PRKAA1, AMPK1)

Function

• catalytic subunit of AMP-activated protein kinase
• regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase
• also regulates cholesterol synthesis via phosphorylation & inactivation of hormone-sensitive lipase & hydroxymethylglutaryl-CoA reductase
• appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted & when 5'-AMP rises in response to fuel limitation &/or hypoxia
• interacts with FNIP1
• binding of AMP results in allosteric activation, inducing phosphorylation on Thr-174 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase & CAB39
• also activated by phosphorylation by CAMKK2
• triggered by a rise in intracellular Ca+2, without detectable changes in the AMP/ATP ratio

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
• contains 1 protein kinase domain

More general terms

• AMP-activated protein kinase-alpha subunit (AMPKa)
• phosphoprotein

Additional terms

• AMP-activated protein kinase, acetyl CoA carboxylase kinase or HMG CoA reductase kinase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5562
• OMIM: https://mirror.omim.org/entry/602739
• UniProt: http://www.uniprot.org/uniprot/Q13131.html