folliculin-interacting protein 1 (FNIP1, KIAA1961)

Function

• may be involved in energy &/or nutrient sensing through the AMPK & mTOR signaling pathways
• interacts with the C-terminus of FLCN, with HSPCA & with the PRKAA1, PRKAB1 & PRKAG1 subunits of 5'-AMP-activated protein kinase (AMPK)
• phosphorylated FLCN & AMPK are preferentially bound
• phosphorylated by AMPK

Structure

belongs to the FNIP1 family

Compartment

cytoplasm

Alternative splicing

named isoforms=3

Expression

• expressed in heart, liver & placenta > kidney & lung

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8TF40.html