BCL2/adenovirus E1B 19 kD protein-interacting protein 3-like; NIP3-like protein X; NIP3L; BCL2/adenovirus E1B 19 kD protein-interacting protein 3A; adenovirus E1B19K-binding protein B5 (BNIP3L, BNIP3A, BNIP3H, NIX)

Function

• induces apoptosis
• interacts with viral & cellular anti-apoptosis proteins
• can overcome the suppressors BCL-2 & BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis
• may function as a tumor suppressor
• inhibits apoptosis induced by BNIP3
• undergoes progressive proteolysis to an 11 kD C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin
• self-associates
• interacts with BNIP3 & STEAP3
• interacts with human adenovirus-2 E1B 19 kD protein

Structure

belongs to the NIP3 family

Compartment

• nucleus envelope
• endoplasmic reticulum
• mitochondrion
• single-pass membrane protein (putative)

More general terms

• mitochondrial protein
• nuclear protein
• membrane protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=665
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:665
• OMIM: https://mirror.omim.org/entry/605368
• UniProt: http://www.uniprot.org/uniprot/O60238.html