BCL2/adenovirus E1B 19 kD protein-interacting protein 3 (BNIP3, NIP3)

Function

• apoptosis-inducing protein
• can overcome BCL2 suppression
• repartitioning Ca+2 between 2 major intracellular Ca+2 stores* in association with BCL2
• binds to BCL2, adenovirus E1B 19 kD protein
• interacts with BNIP3L, Epstein-Barr virus BHRF1

* 2 major intracellular Ca+2 stores* = mitochondria, endoplasmic reticulum

Compartment

• mitochondria, nuclear membrane
• coexpression with the EIB 19-kD protein results in a shift in BNIP3 localization pattern to the nuclear envelope

More general terms

• oligomerizing protein

Additional terms

• adenovirus oncoprotein E1b

Database

• OMIM: https://mirror.omim.org/entry/603293
• UniProt: http://www.uniprot.org/uniprot/Q12983.html