pleckstrin homology domain-containing family F member 1 (PH domain-containing family F member 1, PH & FYVE domain-containing protein 1, phafin-1, lysosome-associated apoptosis-inducing protein containing PH & FYVE domains, apoptosis-inducing protein, zinc finger FYVE domain-containing protein 15, PLEKHF1, APPD, LAPF, ZFYVE15)

Function

• may induce apoptosis through the lysosomal-mitochondrial pathway
• translocates to the lysosome initiating permeabilization of lysosomal membrane resulting in release of CTSD & CTSL into cytoplasm
• triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization resulting in release of PDCD8

Compartment

• nucleus, cytoplasm, perinuclear region, lysosome
• translocates to lysosome during apoptosis

Expression

• expressed in heart, skeletal muscle > brain, thymus, spleen, kidney, liver, small intestine, placenta, lung

More general terms

• pleckstrin homology domain containing family
• zinc finger FYVE domain-containing protein (ZFYVE)

Database

• UniProt: http://www.uniprot.org/uniprot/Q96S99.html