cathepsin-L1 (major excreted protein, MEP, CTSL, CTSL1)

Function

• role in degradation of proteins in lysosomes
• dimer of a heavy & a light chain linked by disulfide bonds
• specificity close to that of papain
• compared to cathepsin B, cathepsin L1 exhibits higher activity toward protein substrates
• little activity on Z-Arg-Arg-NHMec
• no peptidyl-dipeptidase activity

Structure

belongs to the peptidase C1 family

Compartment

lysosome

Laboratory

• cathepsin L in serum/plasma

More general terms

• cysteine proteinase; thiol proteinase
• cathepsin

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1514
• OMIM: https://mirror.omim.org/entry/116880
• UniProt: http://www.uniprot.org/uniprot/P07711.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1514