NF-kappa-B inhibitor zeta (I-kappa-B-zeta, IkappaBzeta, IkB-zeta, molecule possessing ankyrin repeats induced by lipopolysaccharide, MAIL, IL-1 inducible nuclear ankyrin-repeat protein, INAP, NFKBIZ, IKBZ, INAP, MAIL)

Function

• role in regulation of NF-kappa-B transcription factor complexes
• inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation
• inhibits DNA-binding of RELA & NFKB1/p50, & of the NF-kappa-B RELA-NFKB1/p50 heterodimer & the NF-kappa-B NFKB1/p50 homodimer
• seems also to activate NF-kappa-B-mediated transcription
• in vitro, upon association with NFKB1/p50 has transcriptional activation activity &, together with NFKB1/p50 & RELA, is recruited to LCN2 promoters
• promotes transcription of LCN2 & DEFB4
• recruited to IL-6 promoters & activates IL-6 but decreases TNF-alpha production in response to LPS
• seems to be involved in the induction of inflammatory genes activated through TLR/IL-1
• receptor signaling
• may promote apoptosis (putative)
• interacts with NFKB1/p50
• interacts with RELA

Structure

contains 7 ANK repeats

Compartment

• nucleus
• aggregated in dot-like structures
• colocalizes with NCOR2

Alternative splicing

named isoforms=3

Expression

• expressed in peripheral blood leukocytes & lung > liver, placenta > spleen, kidney, skeletal muscle & heart
• induced by TNFA, IL-1 & LPS

More general terms

• ankyrin repeat domain protein (ANKRD)
• nuclear protein

Database

• OMIM: https://mirror.omim.org/entry/608004
• UniProt: http://www.uniprot.org/uniprot/Q9BYH8.html