cyclin-dependent kinase 2-interacting protein (CINP)

Function

• interacts with the components of the replication complex & 2 kinases, CDK2 & CDC7, thereby providing a functional & physical link between CDK2 & CDC7 during firing of the origins of replication
• phosphorylated by CDC7 but not by CDK2

Structure

• homodimer
• interacts with CDK2 & CDC7
• interacts with the components of the replication complex, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 & with ORC2L-containing complexes
• belongs to the CINP family

Compartment

• nucleus
• binds to nuclear under G1 conditions, & dissociates from chromatin with the start of DNA replication

More general terms

• nuclear protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5155
• UniProt: http://www.uniprot.org/uniprot/Q9BW66.html