cryoprecipitate

Introduction

Prepared by slowly thawing fresh frozen plasma at 4-6 degrees C. The precipitate is collected & refrozen.

Components:

• factor VIII: 80-120 units/ unit of cryoprecipitate
• fibrinogen: 200-250 mg/unit
• fibronectin
• factor XIII
• von Willebrand's factor

Indications

• active bleeding in von Willebrand's disease*
• active bleeding with plasma fibrinogen < 100 mg/dL
• treatment of choice for fibrinogen deficiency due to DIC, liver disease or thrombolytic therapy
• dysfibrinogenemia
• hemophilia A (factor VIII is better)
• factor XIII deficiency
• also used for preparing topical fibrin glue for surgical hemostatis

* von Willibrand factor-rich factor VIII concentrate is preferable

Procedure

Transfusions:

• generally pooled for use. 10 units is common
• ABO blood group compatible preferred
• standard 170 micron filter
• repeat transfusions every 8-10 hours

Complications

• transfusion related infection (not virally inactivated)

More general terms

• transfusion component