sororin; cell division cycle-associated protein 5; p35 (CDCA5)

Function

• regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin
• may antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin
• cohesion ensures that chromosome partitioning is accurate in both meiotic & mitotic cells & plays a role in DNA repair
• required for efficient DNA double-stranded break repair
• phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A & relieves the inhibition of WAPAL by CDCA5
• ubiquitinated by the APC/C complex in G1 phase, leading to its degradation (probable)
• interacts with the chromatin-bound cohesin complex
  • interaction is indirect
  • occurs after DNA replication
  • requires acetylation of the cohesin component SMC3
• interacts (via the FGF motif) with PDS5A & PDS5B
  • interaction prevents interaction of PDS5A with WAPAL

Structure

• the KEN box is required for the association with the APC/C complex (putative)
• belongs to the sororin family

Compartment

• nucleus, chromosome, cytoplasm
• associates with nuclear chromatin from S phase until metaphase & is released in the cytoplasm upon nuclear envelope breakdown

Notes

• named sororin after the latin word 'soror', which means 'sister', because of its critical role in sister chromatid cohesion

More general terms

• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=113130
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:113130
• OMIM: https://mirror.omim.org/entry/609374
• UniProt: http://www.uniprot.org/uniprot/Q96FF9.html