sister chromatid cohesion protein PDS5 homolog A (sister chromatid cohesion protein 112, SCC-112, cell proliferation-inducing gene 54 protein, PDS5A, KIAA0648, PDS5, PIG54)

Function

• may contribute to regulation of sister chromatid cohesion during mitosis
• interacts with the cohesin complex
• binds chromatin in a cohesin-dependent manner

Structure

• belongs to the PDS5 family
• contains 1 HEAT repeat
• contains 3 LRR repeats (leucine-rich repeats)

Compartment

• nucleus
• associated with chromatin through most of the cell cycle
• dissociates from chromatin in late prophase, reassociates during late telophase

Alternative splicing

named isoforms=3

Expression

• highest level in colon
• low levels in lung, ovary, breast & kidney
• diminished level in renal tumor tissue
• isoform 3 expressed in kidney
• cell cycle-regulated with highest level in G2 phase

Genetics

• HeLa cells with a diminished level of PDS5A show a mild defect in sister chromatid cohesion.
• HeLa cells with a diminished level of RAD21 show diminished association of PDS5A with chromatin

More general terms

• nuclear protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q29RF7.html