androgen-induced proliferation inhibitor (androgen-induced prostate proliferative shutoff-associated protein AS3, sister chromatid cohesion protein PDS5 homolog B, APRIN, AS3, KIAA0979, PDS5B)

Function

• role in androgen-induced proliferative arrest in prostate cells
• required for maintenance of sister chromatid cohesion during mitosis
• interacts with the cohesin complex
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• contains 3 A.T hook DNA-binding domains
• contains 1 HEAT repeat

Compartment

nucleus

Alternative splicing

named isoforms=5

Expression

• widely expressed
• induced by the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest
• maximum levels occur 18-20 hours after androgen exposure

Pathology

• defects in APRIN may be the cause of some cancers, including esophageal cancer

More general terms

• phosphoprotein
• nuclear protein

Database

• OMIM: https://mirror.omim.org/entry/605333
• UniProt: http://www.uniprot.org/uniprot/Q9NTI5.html