ectoderm-neural cortex protein 1; ENC-1; kelch-like protein 37; nuclear matrix protein NRP/B; p53-induced gene 10 protein (ENC1, KLHL37, NRPB, PIG10)

Function

• actin-binding protein
• role in regulation of neuronal process formation
• role in differentiation of neural crest cells
• substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins
• protein modification; protein ubiquitination
• ubiquitinated & probably targeted for proteasome- independent degradation
• binds to RB1
• hypophosphorylated RB1 associates with ENC1 during neuronal differentiation
• hyperphosphorylated RB1 associates with ENC1 in undifferentiating cells
• part of a complex that contains CUL3, RBX1 & ENC1

Structure

• contains 1 BTB/POZ domain
• contains 6 kelch repeats

Compartment

• nucleus matrix. cytoplasm, cytoskeleton

Expression

• detected in fetal brain tissue
• moderate expression in fetal heart, lung & kidney
• highly expressed in adult brain, particularly high in hippocampus & amygdala
• highly expressed in adult spinal cord
• detected in adult pancreas
• up-regulated upon neuronal differentiation
• induced by TP53/p53

Pathology

• may be down-regulated in neuroblastoma tumors

More general terms

• phosphoprotein
• kelch-like protein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8507
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8507
• OMIM: https://mirror.omim.org/entry/605173
• UniProt: http://www.uniprot.org/uniprot/O14682.html