mortality factor 4-like protein 1 (MORF-related gene 15 protein, transcription factor-like protein MRG15, MSL3-1 protein, HSPC008/HSPC061, MORF4L1, MRG15, FWP006, PP368)

Function

• component of the NuA4 histone acetyltransferase complex (HAT)
• also component of the MSIN3A complex
• MORF4L1 may play role in formation of NuA4 related complexes which lack the HTATIP/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP
• MORF4L1 interacts with RB1 & MYST1
• MORF4L1 may also interact with PHF12 & one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors
• interacts with the N- terminus of MRFAP1
• found in a complex composed of MORF4L1, MRFAP1 & RB1

Structure

belongs to the MRG family

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• protein subunit

Component of

• NuA4 histone acetyltransferase (HAT) complex
• MSIN3A histone deacetylase complex

Database

• OMIM: https://mirror.omim.org/entry/607303
• UniProt: http://www.uniprot.org/uniprot/Q9UBU8.html