cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121, CYFIP2, KIAA1168, PIR121)

Function

• role in T-cell adhesion & p53-dependent induction of apoptosis
• does not bind RNA
• interacts with FMR1, FXR1 & FXR2
• component of WAVE1 complex
• CYFIP2 binds to activated RAC1 which causes WAVE1 complex to dissociate, releasing activated WASF1

Structure

belongs to the CYFIP family

Compartment

• cytoplasm, perinuclear region
• synaptosome
• hghly expressed in the perinuclear region
• enriched in synaptosomes
• treatment with leptomycin-B triggers translocation to nucleus

Alternative splicing

named isoforms=2

RNA editing

• modified positions=320, partially edited
• editing appears to be brain-specific

Pathology

• up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level)

More general terms

• other protein

Component of

• WAVE1 complex

Database

• OMIM: https://mirror.omim.org/entry/606323
• UniProt: http://www.uniprot.org/uniprot/Q96F07.html