hepatitis B virus X-interacting protein; HBV X-interacting protein; HBX-interacting protein (HBXIP, XIP, LAMTOR5)

Function

• when complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, this selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway
• down-regulates hepatitis B virus (HBV) replication
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently
• interacts with SUPV3L1
• interacts with hepatitis B virus (HBV) oncoprotein HBX C-terminus
• suppression of caspase activation by the BIRC5/HBXIP complex is increased in the presence of HBX

Structure

belongs to the HBXIP family

Compartment

cytoplasm

Expression

• expressed in skeletal muscle & cardiac muscle > pancreas, kidney, liver, brain, placenta & lung

Pathology

• elevated levels of expression in liver tissue of patients with chronic hepatitis B infection

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10542
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10542
• OMIM: https://mirror.omim.org/entry/608521
• UniProt: http://www.uniprot.org/uniprot/O43504.html