ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUV3-like protein 1, suppressor of var1 3-like protein 1, SUPV3L1, SUV3)

Function

• ATPase & DNA/RNA helicase able to unwind DNA/DNA, DNA/RNA & RNA/RNA duplexes in the 5'-3' direction
• may protect cells from apoptosis
• helicase activity toward DNA substrate is inhibited by micromolar concentrations of: 5,6-dichloro-1-(beta-D-ribofuranosyl)benzotriazole (DRBT) & 4,5,6,7-tetrabromobenzotriazole (TBBT)
• helicase activity toward RNA substrate is inhibited by elevated concentrations of TBBT
• inhibited by some ring-expanded nucleoside analogs
• interacts with HBXIP

Kinetic parameters:

• KM=41.9 uM for ATP
• Optimum pH is 5.0
• Optimum temperature is 30 degrees Celsius

Cofactor: Mg+2 or Mn+2

Structure

• belongs to the helicase family
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

mitochondrial matrix, nucleus

Expression

broadly expressed

More general terms

• mitochondrial protein
• helicase (DNA unwinding protein, DNA untwisting protein)

Database

• OMIM: https://mirror.omim.org/entry/605122
• UniProt: http://www.uniprot.org/uniprot/Q8IYB8.html