optineurin; optic neuropathy-inducing protein; E3-14.7K-interacting protein; FIP-2; huntingtin-interacting protein L; huntingtin yeast partner L; huntingtin-interacting protein 7; HIP-7; NEMO-related protein; transcription factor IIIA-interacting protein; TFIIIA-intP (OPTN, FIP2, GLC1E, HIP7, HYPL, NRP)

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Function

Compartment

cytoplasm, perinuclear region, Golgi

Expression

Pathology

More general terms

Additional terms

References

  1. Journal Watch 22(6):50, 2002 Rezaie T et al Adult-onset primary open-angle glaucoma caused by mutations in optineurin. Science 295:1077, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11834836
  2. UniProt http://www.uniprot.org/uniprot/Q96CV9.html
  3. GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/OPTN
  4. 4.0 4.1 Vittitow J, Borras T. Expression of optineurin, a glaucoma-linked gene, is influenced by elevated intraocular pressure. Biochem Biophys Res Commun. 2002 Oct 18;298(1):67-74. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12379221
  5. 5.0 5.1 Kamphuis W, Schneemann A. Optineurin gene expression level in human trabecular meshwork does not change in response to pressure elevation. Ophthalmic Res. 2003 Mar-Apr;35(2):93-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12646749

Database