securin; pituitary tumor-transforming gene 1 protein; hPTTG; tumor-transforming protein 1; esp1-associated protein (PTTG1, EAP1, PTTG, TUTR1)

Function

• sister-chromatid separation inhibitor
• DNA repair
• chromosome stability
• negatively regulates transcriptional activity & related apoptosis activity of TP53
• interacts with Ku, RPS10, DNAJA1, ESPL1, TP53
• phosphorylated at Ser-165 by CDC2 during mitosis
• phosphorylated in vitro by ds-DNA kinase
• ubiquitinated by the anaphase promoting complex at the onset of anaphase

Compartment

cytoplasm, nucleus

Expression

• expressed at low level in most tissues
• highly expressed in testes
• low level during G1 phase & S phase
• peaks in M phase; during anaphase, it is degraded

Pathology

• transforming activity when overexpressed
• overexpressed in many patients with pituitary adenomas, primary epithelial neoplasias, & esophageal cancer

More general terms

• phosphoprotein

Additional terms

• securin-2 (pituitary tumor-transforming protein 2, PTTG2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9232
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9232
• OMIM: https://mirror.omim.org/entry/604147
• UniProt: http://www.uniprot.org/uniprot/O95997.html