securin-2 (pituitary tumor-transforming protein 2, PTTG2)

Structure

• N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway (putative)
• belongs to the securin family

Compartment

cytoplasm, nucleus

Alternative splicing

named isoforms=2

Expression

• expressed at low levels in the pituitary, liver, spleen, prostate, testis, ovary, small intestine & colon
• expressed in various pituitary, testicular, liver & ovarian tumors

More general terms

• uncharacterized protein

Additional terms

• securin; pituitary tumor-transforming gene 1 protein; hPTTG; tumor-transforming protein 1; esp1-associated protein (PTTG1, EAP1, PTTG, TUTR1)

Database

• OMIM: https://mirror.omim.org/entry/604231
• UniProt: http://www.uniprot.org/uniprot/Q9NZH5.html