vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kD protein-interacting protein 1, transformation-related gene 8 protein, TRG-8, BNIP1, NIP1, SEC20L, TRG8)

Function

• SNARE protein
• targeting & fusion of Golgi-derived retrograde transport vesicles with the ER
• maintenance of ER network
  • silencing of BNIP1 disrupts ER morphology
• suppression of cell death
• component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L & SEC22B
• interacts directly with STX18, RINT1/TIP20L & NAPA
• interacts with ZW10 through RINT1
• interacts with BCL2 & adenovirus E1B 19 kD protein

Compartment

endoplasmic reticulum

Alternative splicing

named isoforms=4

Expression

• isoform 1 expressed in heart, brain, liver, skeletal muscle, pancreas
• isoform 3 expressed in placenta, lung, kidney
• isoform 4 expressed in testis, small intestine

More general terms

• SNARE protein

Additional terms

• adenovirus oncoprotein E1b

Database

• OMIM: https://mirror.omim.org/entry/603291
• UniProt: http://www.uniprot.org/uniprot/Q12981.html