RAD50-interacting protein 1; RAD50 interactor 1; HsRINT-1; RINT-1 (RINT1)

Function

• role in membrane traffic between endoplasmic reticulum & Golgi
• cell cycle checkpoint control (putative)
• telomere length control
• interacts with RAD50 during late S phase & G2/M phase.
• component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, & SEC22B
  • within the SNARE complex, interacts with BNIP1/SEC20L
• interacts with ZW10
• interacts with RBL2, preferentially with active, hypophosphorylated form

Structure

• belongs to the RINT1 family
• contains 1 RINT1/TIP20 domain

Compartment

• cytoplasm, endoplasmic reticulum, peripheral membrane

Expression

expressed throughout the cell cycle

More general terms

• other protein

Additional terms

• DNA repair protein RAD50; hRAD50 (RAD50)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=60561
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:60561
• OMIM: https://mirror.omim.org/entry/610089
• UniProt: http://www.uniprot.org/uniprot/Q6NUQ1.html