single Ig IL-1-related receptor; single Ig IL-1R-related molecule; single immunoglobulin domain-containing IL1R-related protein; Toll/interleukin-1 receptor 8; TIR8 (SIGIRR)

Function

• negative regulator of Toll-like receptor & IL1R signaling
• attenuates recruitment of receptor-proximal signaling components to the TLR4 receptor
• interferes with heterodimerization of Il1R1 & IL1RAP
• interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9, TRAF6
• upon IL-1 stimulation found in a complex of: IL1R1, SIGIRR, MYD88, IRAK1, TRAF6
• upon stimulation with LPC found in a complex of: TLR4, SIG1IR, MYD88, IRAK1, TRAF6.

Structure

• belongs to the interleukin-1 receptor family
• contains 1 Ig-like C2-type domain (immunoglobulin-like)
• contains 1 TIR domain

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• expressed in epithelial tissues, kidney, lung, gut

More general terms

• cell surface receptor
• phosphoprotein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5930
• OMIM: https://mirror.omim.org/entry/605478
• UniProt: http://www.uniprot.org/uniprot/Q6IA17.html