Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2, Graf-related protein 2, ARHGAP10, GRAF2)
Jump to navigation
Jump to search
Function
- GTPase activator for the small GTPases RhoA & Cdc42 by converting them to an inactive GDP-bound state
- essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases
- inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity & changes its localization from the nucleus to the perinuclear region.
- stabilizes PAK-2p34 thereby increasing stimulation of cell death (putative)
- interacts with PKN3
- interacts with caspase-activated PAK2 proteolytic fragment PAK-2p34; the interaction does not affect ARHGAP10 GTPase activation activity towards RHOA & CDC42
- interacts via its SH3 domain with PTK2
- interacts with PTK2B; the interaction negatively regulates ARHGAP10 GTPase-activating activity (putative)
- phosphorylated
- phosphorylated in vitro by constitutive active PKN3
Structure
- contains 1 BAR domain
- contains 1 PH domain
- contains 1 Rho-GAP domain
- contains 1 SH3 domain
Compartment
- cytoplasm (putative), perinuclear region, cell membrane
- association to cell membrane is dependent on PH domain
Expression
- high levels of expression in heart & skeletal muscle