serine/threonine protein kinase N3; protein kinase PKN-beta; protein-kinase C-related kinase 3 (PKN3, PKNBETA)

Function

• serine/threonine protein kinase
• two specific sites, Thr-718 (activation loop of kinase domain) & Thr-860 (turn motif), need to be phosphorylated for full activation (putative)
• autophosphorylated

Structure

• the C1 domain does not bind the diacylglycerol (DAG)
• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily
• contains 1 AGC-kinase C-terminal domain
• contains 1 protein kinase domain
• contains 3 REM (Hr1) repeats

Compartment

• nucleus, cytoplasm, perinuclear region
• nuclear & perinuclear Golgi region

Expression

• expressed in prostate tumors & various cancer cell lines
• not expressed in adult tissues

More general terms

• serine/threonine kinase
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29941
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:29941
• OMIM: https://mirror.omim.org/entry/610714
• UniProt: http://www.uniprot.org/uniprot/Q6P5Z2.html