transcriptional enhancer factor TEF-3; TEA domain family member 4; TEAD-4; transcription factor 13-like 1; transcription factor RTEF-1 (TEAD4, RTEF1, TCF13L1, TEF3)

Function

• transcription factor
• role in the Hippo signaling pathway, a pathway involved in organ size control & tumor suppression
• mediates expression of YAP1 & WWTR1/TAZ, thus regulating cell proliferation, migration & epithelial mesenchymal transition (EMT) induction
• binds specifically & non-cooperatively to the sph & GT-IIC 'enhansons' (5'-GTGGAATGT-3') & activates transcription
• binds to the M-CAT motif interacts with YAP1 & WWTR1/TAZ

Structure

contains 1 TEA DNA-binding domain

Compartment

nucleus

Expression

• preferentially expressed in skeletal muscle
• lower expression in pancreas, placenta, & heart

More general terms

• TEA domain family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7004
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7004
• OMIM: https://mirror.omim.org/entry/601714
• UniProt: http://www.uniprot.org/uniprot/Q15561.html