transcriptional enhancer factor TEF-4; TEA domain family member 2; TEAD-2 (TEAD2, TEF4)

Function

• transcription factor
• role in the Hippo signaling pathway, a pathway involved in organ size control & tumor suppression
• mediates expression of YAP1 & WWTR1/TAZ, thus regulating cell proliferation, migration & epithelial mesenchymal transition (EMT) induction
• binds to the SPH & GT-IIC 'enhansons' (5'-GTGGAATGT-3')
• may be involved in regulation of neural development
• binds to the M-CAT motif
• interacts with YAP1 & WWTR1/TAZ

Structure

• contains 1 TEA DNA-binding domain

Compartment

nucleus

More general terms

• TEA domain family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8463
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8463
• OMIM: https://mirror.omim.org/entry/601729
• UniProt: http://www.uniprot.org/uniprot/Q15562.html