elk1 proto-oncogene protein; ETS domain-containing protein Elk-1 (ELK1)
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Function
- stimulates transcription
- binds to purine-rich DNA sequences
- can form a ternary complex with the serum response factor & the ETS & SRF motifs of the fos serum response element
- interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity
- sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation & diminished transactivator activity
- regulates nuclear retention
- on mitogenic stimulation, phosphorylated on C-terminal Ser & Thr by MAPK1
- Ser-383 & Ser-389 are the preferred sites for MAPK1
- in vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE & SRF
- phosphorylation leads to loss of sumoylation & restores transcriptional activator activity
Structure
- belongs to the ETS family
- has 3 regions of homolgy with SAP-1 protein
- contains 1 ETS DNA-binding domain ETS domain located in the amino terminus of the protein
Compartment
Alternative splicing
named isoforms=2
Expression
lung & testis
More general terms
References
- ↑ Macleod K, Leprince D, Stehelin D. The ets gene family. Trends Biochem Sci. 1992 Jul;17(7):251-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1502727
- ↑ Sun H, Tonks NK, Bar-Sagi D. Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1. Science. 1994 Oct 14;266(5183):285-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7939666 [p62TCF]
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2002
- ↑ UniProt http://www.uniprot.org/uniprot/P19419.html