elk4 proto-oncogene protein; serum response factor [SRF] accessory protein-1; SAP-1 (ELK4)

Function

• forms a ternary complex with the serum response factor (SRF) over c-fos Serum Response Element
• requires DNA-bound SRF for ternary complex formation & makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously

Structure

• belongs to the ETS family
• contains 1 ETS DNA-binding domain

Compartment

nucleus

Alternative splicing

• named isoforms=2
• SRF accessory protein-1 alpha (SRF1A) - 58 kD
• SRF accessory protein-1 beta (SRF1B) - 62 kD

More general terms

• Ets family protein

Database

• OMIM: https://mirror.omim.org/entry/600246
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2005
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2005
• UniProt: http://www.uniprot.org/uniprot/P28324.html