transcription factor MafK; erythroid transcription factor NF-E2 p18 subunit (MAFK)
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Function
- small mafs behave as transcriptional repressors when they dimerize among themselves
- however, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins & recruiting them to specific DNA-binding sites
- can form high affinity
- small Maf proteins heterodimerize with Fos & may act as competitive repressors of the NF-E2 transcription factor
- heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 & NFE2L3/NRF3
Structure
- homodimer or heterodimer
- belongs to the bZIP family, Maf subfamily
- significant homology to protein product of c-maf
- contains 1 bZIP domain
- small mafs lack a putative transactivation domain
Compartment
Expression
ubiquitously expressed
More general terms
Component of
References
- ↑ Andrews NC, Erdjument-Bromage H, Davidson MB, Tempst P, Orkin SH. Erythroid transcription factor NF-E2 is a haematopoietic- specific basic-leucine zipper protein. Nature. 1993 Apr 22;362(6422):722-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8469283
- ↑ Andrews NC, Kotkow KJ, Ney PA, Erdjument-Bromage H, Tempst P, Orkin SH. The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11488-92. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8265578