erythroid-restricted nuclear factor E2
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Function
- transcription factor that recognizes the extended AP1-site [(C/T)TGCTCA(C/G)TCA(T/C)] found in the upstream locus control regions of the alpha-globin gene cluster & beta-globin gene cluster
- NF-E2 links intestinal transport of iron to erythropoiesis[3]
More general terms
References
- ↑ Andrews NC, Erdjument-Bromage H, Davidson MB, Tempst P, Orkin SH. Erythroid transcription factor NF-E2 is a haematopoietic- specific basic-leucine zipper protein. Nature. 1993 Apr 22;362(6422):722-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8469283
- ↑ Andrews NC, Kotkow KJ, Ney PA, Erdjument-Bromage H, Tempst P, Orkin SH. The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11488-92. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8265578
- ↑ 3.0 3.1 The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996 pg 1317-1325