POU domain, class 3, transcription factor 1; octamer-binding protein 6; Oct-6; octamer-binding transcription factor 6; OTF-6; POU domain transcription factor SCIP (POU3F1, OCT6, OTF6)

Introduction

A transcriptional repressor of myelin-specific genes, expressed in dividing schwann cells.

Function

• transcription factor & DNA-binding protein
• binds to the octamer motif 5'-ATTTGCAT-3'
• role in early embryogenesis & neurogenesis (putative)

Structure

• belongs to the POU transcription factor family, class- 3 subfamily
• contains 1 homeobox DNA-binding domain
• contains 1 POU-specific domain

Compartment

nucleus

Expression

• expressed in embryonal stem cells & in the developing brain

More general terms

• octamer transcription factor
• transcriptional silencer (transcriptional repressor)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5453
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5453
• OMIM: https://mirror.omim.org/entry/602479
• UniProt: http://www.uniprot.org/uniprot/Q03052.html