proline-rich nuclear receptor coactivator 2 (PNRC2)

Function

• role in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex & the NMD machinery
• may act by targeting the NMD machinery to the P-body & recruiting the decapping machinery to aberrant mRNAs
• required for UPF1/RENT1 localization to the P-body
• also acts as a nuclear receptor coactivator
• may play a role in controlling the energy balance between energy storage & energy expenditure
• interacts with UPF1/RENT1
  • preferentially interacts with hyperphosphorylated form
• interacts with DCP1A
• interacts with many nuclear receptors including ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR & RXR

Structure

• the interaction between PNRC2 & nuclear receptors is dependent on the SH3 binding motif
• belongs to the PNRC family, PNRC2 subfamily

Compartment

• nucleus, cytoplasm, P-body

Alternative splicing

named isoforms=2

Expression

• expressed in heart, lung, muscle, brain

More general terms

• transcriptional adaptor protein; transcriptional coactivator

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=100996
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55629
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55629
• OMIM: https://mirror.omim.org/entry/611882
• UniProt: http://www.uniprot.org/uniprot/Q9NPJ4.html