interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8 (IL17A, IL-17A, CTLA-8)
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Function
- induces stromal cells to produce proinflammatory & hematopoietic cytokines
- enhances surface expression of the ICAM1 in fibroblasts
Structure
homodimer
Compartment
- secreted
- found both in glycosylated & nonglycosylated forms
Expression
restricted to activated memory T-cells
Pathology
- appears to play a role in chronic plaque psoriasis[3]
More general terms
References
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3605
- ↑ UniProt http://www.uniprot.org/uniprot/Q16552.html
- ↑ 3.0 3.1 Papp KA et al. Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. N Engl J Med 2012 Mar 29; 366:1181. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22455412
Leonardi C et al. Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl J Med 2012 Mar 29; 366:1190. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22455413 - ↑ R&D systems' cytokine mini-reviews: IL-17 http://www.rndsystems.com/molecule_detail.aspx?m=1674
- ↑ Wikipedia; Note: interleukin-17 entry http://en.wikipedia.org/wiki/interleukin_17
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/il17/