C-C motif chemokine 8; HC14; monocyte chemoattractant protein 2; monocyte chemotactic protein 2; MCP-2; small-inducible cytokine A8; contains: MCP-2(6-76) (CCL8 MCP2 SCYA10 SCYA8)

Function

• chemotactic factor that attracts monocytes, lymphocytes, basophils & eosinophils
• may play a role in neoplasia & inflammatory host responses
• can bind heparin
• N-terminal processed form MCP-2(6-76) is produced by proteolytic cleavage after secretion from peripheral blood monocytes
  • processed form MCP-2(6-76) does not have monocyte chemotactic activity, but inhibits chemotactic effect predominantly of CCL7, & also of CCL2 & CCL5 & CCL8

Structure

• monomer or homodimer; in equilibrium
• belongs to the intercrine beta (chemokine CC) family

Compartment

secreted

Expression

• highest expression found in the small intestine & peripheral blood cells
• intermediate levels seen in heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord & pancreas
• low levels seen in the brain, liver, spleen & prostate
• induced by IFN-gamma, mitogens & IL-1

More general terms

• CC chemokine; beta chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6355
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6355
• OMIM: https://mirror.omim.org/entry/602283
• UniProt: http://www.uniprot.org/uniprot/P80075.html