CD1A; T-cell surface glycoprotein CD1a; T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen (Leu6, HTA1)

Function

• antigen-presenting protein that binds self & non-self lipid & glycolipid antigens & presents them to T-cell receptors on natural killer T-cells
• heterodimer with B2M (beta-2-microglobulin)
• interacts with CD74

Structure

contains 1 Ig-like domain (immunoglobulin-like)

Compartment

• cell membrane
• endosome membrane
• subject to intracellular trafficking between the cell membrane & endosomes
• localizes to cell surface lipid rafts

Expression

• expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, & in various other tissues
• normal B cells stain negative with antibody

Pathology

• expressed in:
  • dendritic cells in dermis/epidermis of benign inflammatory skin disorders
  • Langerhans cell histiocytosis
  • myeloid leukemias
  • some B cell malignancies
  • dendritic cells in most peripheral cutaneous T cell lymphomas
• most B cell malignancies stain negative with antibody

More general terms

• CD1

Database

• UniProt: http://www.uniprot.org/uniprot/P06126.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=909
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:909
• OMIM: https://mirror.omim.org/entry/188370