CD1

Compartment

• during protein synthesis & maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized & pass through endosomes, before trafficking back to the cell surface

Expression

• cortical thymocytes ~70%
• activated T cells
• Langerhans cells
• interdigitating dendritic cells

• pre-T ALL with cortical thymocyte phenotype
• Langerhans cell histiocytosis.

• mature peripheral T cells stain negatively with antibody.

More general terms

• CD antigen
• glycoprotein
• immunoglobulin superfamily protein

More specific terms

• CD1A; T-cell surface glycoprotein CD1a; T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen (Leu6, HTA1)
• CD1C; T-cell surface glycoprotein CD1c
• CD1D; T-cell surface glycoprotein CD1d; R3G1 (CD1D)
• CD1E; T-cell surface glycoprotein CD1e; R2G1 (CD1E)
• T-cell surface glycoprotein CD1b; CD1b (CD1B)

Database

• OMIM: https://mirror.omim.org/entry/188370