CD1C; T-cell surface glycoprotein CD1c

Function

• antigen-presenting protein that binds self & non-self lipid & glycolipid antigens & presents them to T-cell receptors on natural killer cells
• heterodimer with B2M (beta-2-microglobulin)

Structure

contains 1 Ig-like domain (immunoglobulin-like)

Compartment

• cell membrane, endosome membrane
• subject to intracellular trafficking between the plasma membrane & endosomes
• during protein synthesis & maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized & pass through endosomes or lysosomes, before trafficking back to the cell surface

Expression

• expressed on cortical thymocytes, certain T-cell leukemias, & in various other tissues
• normal B cells, stain negative with antibody
• may stain a subset of normal peripheral B cells

Pathology

• myeloid leukemias
• some B cell malignancies

More general terms

• CD1

Database

• UniProt: http://www.uniprot.org/uniprot/P29017.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=911
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:911
• OMIM: https://mirror.omim.org/entry/188340