CD1E; T-cell surface glycoprotein CD1e; R2G1 (CD1E)

Function

• required for the presentation of glycolipid antigens on the cell surface
• mono-ubiquitinated
• proteolytically cleaved in endosomes to yield a soluble form
• heterodimer with B2M (beta-2-microglobulin)

Structure

contains 1 Ig-like domain (immunoglobulin-like)

Compartment

• Golgi membrane, endosome lumen. lysosome lumen
• predominantly localized in the trans-Golgi network in immature dendritic cells, & as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells

Expression

-expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, & in various other tissues

More general terms

• CD1

Database

• UniProt: http://www.uniprot.org/uniprot/P15812.html
• OMIM: https://mirror.omim.org/entry/188411
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=913