RNA-binding protein 5; RNA-binding motif protein 5; tumor suppressor LUCA15; protein G15; renal carcinoma antigen NY-REN-9 (RBM5)

Function

• component of the spliceosome A complex
• regulates alternative splicing of a number of mRNAs
• may modulate splice site pairing after recruitment of the U1 & U2 snRNPs to the 5' & 3' splice sites of the intron
• may both positively & negatively regulate apoptosis by regulating alternative splicing of several genes involved in this process, including FAS & CASP2/caspase-2
• in the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis
• in the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis
• appears to dissociate from the spliceosome upon formation of the spliceosome B complex
• interacts with U2AF2; interaction is direct
• interacts with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 & SNRNP200; interactions may be indirect

Structure

• belongs to the RBM5/RBM10 family
• contains 1 C2H2-type Zn+2 finger
• contains 1 G-patch domain
• contains 1 RanBP2-type Zn+2 finger
• contains 2 RRM domain (RNA recognition motif)s

Compartment

nucleus

Alternative splicing

named isoforms=5

Expression

• isoform 5 is widely expressed in normal tissues & is expressed at increased levels in T-cell leukemia cell lines

More general terms

• nuclear protein
• RNA-binding motif protein
• zinc finger protein
• phosphoprotein

Component of

• spliceosome A complex (prespliceosome)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10181
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10181
• OMIM: https://mirror.omim.org/entry/606884
• UniProt: http://www.uniprot.org/uniprot/P52756.html