apoptotic chromatin condensation inducer in the nucleus; acinus (ACIN1, ACINUS, KIAA0670)

Function

• component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs
• induces apoptotic chromatin condensation after activation by CASP3
• undergoes proteolytic cleavage
  • the processed form is active, in contrast to the inactive uncleaved form
• forms heterodimers with RNPS1
• found in a heterotrimeric complex with ACIN1, RNPS1 & SAP18
• interacts with API5

Structure

contains 1 SAP domain

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

ubiquitous

More general terms

• pro apoptotic protein
• nuclear protein
• phosphoprotein

Additional terms

• acinus of gland
• apoptosis

Component of

• exon junction complex (EJC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22985
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22985
• OMIM: https://mirror.omim.org/entry/604562
• UniProt: http://www.uniprot.org/uniprot/Q9UKV3.html