apoptosis inhibitor 5; API-5; antiapoptosis clone 11 protein; AAC-11; cell migration-inducing gene 8 protein; fibroblast growth factor 2-interacting factor; FIF; protein XAGL (API5)

Function

• antiapoptotic factor
• protein assembly (putative)
• negatively regulates ACIN1
  • by binding to ACIN1, suppresses ACIN1 cleavage from CASP3 & ACIN1-mediated DNA fragmentation
  • suppresses E2F1-induced apoptosis
• depletion enhances the cytotoxic action of chemotherapy acetylation at Lys-251 impairs antiapoptotic function
• monomer
• interacts with FGF2 & ACIN1

Structure

• two regions, an N-terminal (aa 96-107) & a C-terminal (aa 274-311) are required for binding FGF2
• belongs to the API5 family

Compartment

• mainly nucleus, also cytoplasm
• isoform 3 is cytoplasmic

Alternative splicing

• named isoforms=5
• additional isoforms seem to exist

Expression

• expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas
• highest levels in heart, pancreas, placenta

More general terms

• phosphoprotein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8539
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8539
• OMIM: https://mirror.omim.org/entry/609774
• UniProt: http://www.uniprot.org/uniprot/Q9BZZ5.html