dynamin-binding protein; scaffold protein tuba (DNMBP, KIAA1010)

Function

• scaffold protein
• links dynamin with actin-regulating proteins
• may play a role in membrane trafficking between the cell surface & the Golgi (putative)
• binds DNM1 via its N-terminal SH3 domains
• the C-terminal SH3 domain binds a complex containing actin, tubulin, Hsp70 & actin-regulatory proteins, such as ENAH, EVL, WASL, WIRE, CR16, WAVE1 & NAP1L1 (putative)
• interacts with FASLG

Structure

• contains 1 BAR domain
• contains 1 DH (DBL-homology) domain
• contains 6 SH3 domains

Compartment

• cytoplasm, cytoskeleton (putative)
• Golgi; Golgi stack (putative)
• cell junction, synapse (putative)
• localized to synapses & Golgi stacks (putative)

Alternative splicing

named isoforms=2

Expression

• expressed in heart, brain, lung, liver, skeletal muscle, kidney & pancreas

More general terms

• scaffold protein

Additional terms

• dynamin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23268
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23268
• OMIM: https://mirror.omim.org/entry/611282
• UniProt: http://www.uniprot.org/uniprot/Q6XZF7.html