WAS/WASL-interacting protein family member 3 (corticosteroids & regional expression protein 16 homolog, WIPF3, CR16)

Function

• may be a regulator of cytoskeletal organization
• may have a role in spermatogenesis (putative)
• interacts with WASL, & monomeric & filamentous actin

Structure

• the WH2 domain is found in a number of putative actin- binding proteins (putative)
• the profilin-binding motif has been implicated in the interaction with profilin & SH3 domains (putative)
• the KLKR motif is essential for G-actin binding & for actin polymerization (putative)
• belongs to the verprolin family
• contains 1 WH2 domain

Compartment

• cytoplasm

in hippocampal neurons. colocalizes with WASL in the cell body, axons & the growth cone

More general terms

• cytoskeletal protein

Database

• UniProt: http://www.uniprot.org/uniprot/A6NGB9.html